J&J COVID vaccine may pose 'small possible risk' of rare neurological syndrome, CDC says

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The U.S. Centers for Disease Control and Prevention said connected Monday that it has received uncommon reports of Guillain-Barré syndrome among radical who got Johnson & Johnson's Janssen shot. The vaccine has been approved successful Canada but ne'er used.

Boxes of COVID-19 vaccine from U.S. pharmaceutical institution Johnson & Johnson developed with Janssen are pictured astatine a cardinal vaccine warehouse successful Germany. The vaccine lone requires 1 dose and has been approved successful Canada but ne'er utilized here. (Ronny Hartmann/dpa/The Associated Press)

Johnson & Johnson's COVID-19 vaccine whitethorn airs a "small imaginable risk" of a uncommon but perchance unsafe neurological reaction, U.S. wellness officials said Monday.

The Centers for Disease Control and Prevention said successful a connection it has received reports of 100 radical who got J&J's Janssen shot developing Guillain-Barré syndrome, an immune strategy upset that tin origin musculus weakness and occasionally paralysis.

That fig represents a tiny fraction of the astir 13 cardinal Americans who person received the one-dose vaccine. Most cases of the broadside effect were reported successful men — galore 50 years aged and up — and usually astir 2 weeks aft vaccination.

The CDC said it would inquire its sheet of extracurricular vaccine experts to reappraisal the contented astatine an upcoming meeting.

J&J didn't instantly respond to The Associated Press's request for comment. 

Earlier connected Monday, J&J issued a statement saying it was successful discussions with the U.S. Food and Drug Administration astir the uncommon cases of Guillain-Barré. 

"The accidental of having this hap is precise low," the connection said. The institution besides said that the number of reported cases of Guillain-Barré after usage of the vaccine exceeded the fig of cases usually expected successful the colonisation by a "small degree." 

The U.S. authorities said the vaccines astir utilized successful the U.S., made by Pfizer and Moderna, amusement nary hazard of the upset aft much than 320 cardinal doses person been administered.

Guillain-Barré syndrome occurs erstwhile the body's immune strategy mistakenly attacks immoderate of its nervus cells, causing musculus weakness and sometimes paralysis that typically is temporary. An estimated 3,000 to 6,000 radical make the syndrome each twelvemonth successful the U.S., according to the CDC.

Most radical who endure from Guillain-Barré recover fully, according to the CDC's website, but determination person been cases of imperishable nervus damage.  

Syndrome can beryllium triggered by flu, different infections

Vaccines historically supply wide extortion with small hazard but travel with occasional broadside effects conscionable similar different drugs and aesculapian therapies. The 3 COVID-19 vaccines utilized successful the U.S. were each tested successful tens of thousands of people, but adjacent specified immense studies can't regularisation retired highly uncommon broadside effects.

The CDC and the FDA person been monitoring broadside effect reports submitted by physicians, drugmakers and patients to a national vaccine information database.

Guillain-Barré can beryllium triggered by a fig of infections, including the flu, cytomegalovirus and Zika virus. But determination person besides been uncommon cases successful which radical make the upset days oregon weeks aft receiving definite vaccines.

J&J's vaccine was highly anticipated due to the fact that of its one-and-done formulation and easy-to-ship refrigeration. But aboriginal on, it was linked to different uncommon risk, of humor clots, and the institution hasn't been capable to nutrient arsenic overmuch arsenic expected due to the fact that of problems astatine a Baltimore mill that helps marque the shots.

Not utilized successful Canada

Health Canada approved J&J's Janssen vaccine but it has ne'er been utilized successful Canada. There besides doesn't look to beryllium immoderate confirmed program to bash so.  

Public Services and Procurement Minister Anita Anand recently said the Johnson & Johnson declaration remains successful spot and Canada could gully connected supplies from this institution astatine a aboriginal date.

But with millions much mRNA shots from Pfizer and Moderna set to arrive in the coming weeks, she said shipments from J&J whitethorn not beryllium necessary.

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